Survival Syndrome
what are the survival rates for Richter’s syndrome after treatment and what is the treatment for this?
Richters Syndrome is basically transformation of CLL, to be more specific CLL to diffuse large B cell Lymphoma.
Median survival with conventional chemotherapy is less than 6 months. Therapy with more recent therapeutic regimens, such as hyperCVXD (fractionated cyclophosphamide, vincristine, liposomal daunorubicin, and dexamethasone), augmented hyperCVXD, and yttrium-90 ibritumomab tiuxetan, has not produced major improvements in response rates or overall survival. Current data indicate that the transformation of chronic lymphocytic leukemia to a large-cell or immunoblastic lymphoma is associated with abnormalities in cell cycle regulation However, the critical event leading to transformation is unclear. Given the poor prognosis of patients with Richter’s syndrome, it is considered that every effort should be made to enroll these patients into clinical trials evaluating novel agents with the appropriate correlative studies. In all cases when detailed medical information is required, you would be advised to contact your doctor or oncologist.
I add a link containing details of this subject by Apostolia Maria Tsimberidou, MD, PhD .
http://utmext01a.mdacc.tmc.edu/
dept/pub/resrepv2.nsf/all+
departments/453131CF06796
47D8625720000831E24
Hope this helps
matador 89
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